Regulation of Fasting Fuel Metabolism by Toll-Like Receptor 4

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Regulation of Fasting Fuel Metabolism by Toll-Like Receptor 4

OBJECTIVE Toll-like receptor 4 (TLR4) has been reported to induce insulin resistance through inflammation in high-fat-fed mice. However, the physiological role of TLR4 in metabolism is unknown. Here, we investigated the involvement of TLR4 in fasting metabolism. RESEARCH DESIGN AND METHODS Wild-type and TLR4 deficient (TLR4(-/-)) mice were either fed or fasted for 24 h. Glucose and lipid leve...

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ژورنال

عنوان ژورنال: Diabetes

سال: 2010

ISSN: 0012-1797,1939-327X

DOI: 10.2337/db10-0418